|
T3230 |
NLRP3-IN-2
|
5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide,NLRP3 Inflammasome Inhibitor I |
NOD-like Receptor (NLR)
,
NOD
|
|
NLRP3-IN-2 (5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide), an intermediate capable of synthesizing glibenclamide, exerts an inhibitory effect on the formation of NLRP3 inflammatory vesicles in cardiomyocytes, limiting i... |
|
T15052 |
Dapansutrile
|
|
NOD-like Receptor (NLR)
,
NOD
|
|
Dapansutrile is a potent, selective and orally active NLRP3 inflammasome inhibitor, with Anti-inflammatory and analgesic activity. |
|
T8828 |
CP 424174
|
|
IL Receptor
|
|
CP 424174 is an inhibitor of IL-1β post-translational processing with IC50 of 210 nM. Inhibits the formation of mature IL-1β. Indirectly inhibits NLRP3. Active in vivo and orally bioavailable. |
|
T28178 |
NLRP3-IN-9
|
INF-4E,INF 4E,INF4E |
NOD
|
|
NLRP3-IN-9 (INF-4E) is an inhibitor of NLRP3 ATPase and caspase-1. NLRP3-IN-9 acts by irreversibly trapping thiol nucleophiles, which prevents both ATP- and nigericin-triggered pyroptosis of human THP-1 cells in a time- ... |
|
T0342 |
Carvedilol phosphate hemihydrate
|
Carvedilol phosphate,BM 14190 (phosphate hemihydrate) |
VEGFR
,
Others
,
Potassium Channel
,
LDL
,
Integrin
,
Gap Junction Protein
,
NADPH
,
Adrenergic Receptor
,
Autophagy
|
|
Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intrinsic sympathom... |
|
T20731 |
Brilliant blue G-250
|
BBG,Acid blue 90, Coomassie Brilliant Blue G,Brilliant Blue G |
P2X Receptor
|
|
Brilliant blue G-250 (Acid blue 90, Coomassie Brilliant Blue G) is an antagonist of the P2X7 purinergic receptor. |
|
T9222 |
Emlenoflast
|
MCC7840 |
NOD-like Receptor (NLR)
,
NOD
|
|
Emlenoflast (MCC7840) is a selective inhibitor of NLRP3 inflammasome. |
|
T61392 |
NLRP3-IN-10
|
ZVN26391 |
NOD
|
|
NLRP3-IN-10 (ZVN26391) is a potent NLRP3 inhibitor. NLRP3-IN-10 inhibits IL-1β release with an IC50 value of 251.1 nM. NLRP3-IN-10 attenuates ASC speck formation, leading to suppress activation of NLRP3 inflammasome. |
|
T25548 |
JC124
|
JC 124,JC-124 |
NOD
|
|
JC124 is an inhibitor of NLRP3 Inflammasome and exhibits neuroprotective and anti-inflammatory activities. |
|
T60404 |
NLRP3/AIM2-IN-2
|
|
AIM2
|
|
NLRP3/AIM2-IN-2 is a novel potent inhibitor with different species-specific effects on NLRP3 and AIM2 inflammasome dependent pyroptosis with IC50 of 0.2392 ± 0.0233 μ M. |
|
T27841 |
Lobeglitazone Sulfate
|
CKD501 Sulfate,CKD501,CKD-501 Sulfate,CKD 501 Sulfate,CKD 501,CKD-501,Lobeglitazone Sulfate. trade name Duvie, Chong Kun Dang |
NOD
|
|
Lobeglitazone Sulfate（CKD-501 Sulfate） is a novel thiazolidinedione with anti-inflammatory activity that inhibits LPS-induced NLRP3 inflammasome activation and hepatic inflammation, and can be used in the study of type 2... |
|
T13375 |
YQ128
|
|
IL Receptor
,
NOD-like Receptor (NLR)
,
NOD
,
Interleukin
|
|
YQ128 is a potent and selective inhibitor of second-generation NLRP3 (NOD-like receptor P3) inflammasome(IC50 of 0.30 µM), with anti-inflammatory activity. |
|
T60442 |
NLRP3/AIM2-IN-3
|
|
NOD
,
AIM2
|
|
NLRP3/AIM2-IN-3 is a unique molecule that inhibits NLRP3 and AIM2 inflammasome activation in a species-specific manner. It has an IC50 value for cell lysis of 0.077 ± 0.008 μ M. NLRP3/AIM2-IN-3 is a potent inhibitor of N... |
|
T3701 |
MCC950
|
CP-456773 |
NOD
|
|
|
|
T77675 |
TNKS-2-IN-1
|
|
PARP
,
Wnt/beta-catenin
,
Antibiotic
|
|
TNKS-2-IN-1 is a TNKS-2 inhibitor.TNKS-2-IN-1 inhibits TNKS-1 and TNKS-2 with IC50s of 259 nM and 1100 nM, respectively.TNKS-2-IN-1 has antimicrobial activity against E. coli and S. aureus.TNKS-2-IN-1 inhibits the releas... |
|
T9222L |
Emlenoflast sodium
|
MCC7840 sodium |
NOD
|
|
Emlenoflast sodium (MCC7840 sodium), a sulfonylurea, is a selective NLRP3 inflammasome inhibitor with an IC50 value of less than 100 nM for NLRP3 inflammasome, and can be used in the study of inflammatory diseases. |
|
T78168 |
NLRP3-IN-17
|
|
NOD-like Receptor (NLR)
|
|
NLRP3-IN-17 is a potent, selective, and orally active inhibitor of the NLRP3 inflammasome, demonstrating an IC50 of 7 nM. It effectively inhibits NLRP3-dependent IL-1β secretion in mice, making it a valuable compound for... |
|
T78894 |
NLRP3-IN-21
|
|
NOD-like Receptor (NLR)
|
|
NLRP3-IN-21 (compound L38) is an inhibitor of the NLRP3 inflammasome that possesses anti-inflammatory properties. It suppresses the activation of the NLRP3 inflammasome and pyroptosis by inhibiting gasdermin D cleavage, ... |
|
T62809 |
NLRP3-IN-7
|
|
|
|
NLRP3-IN-7 (Compound 36) is a selective inhibitor of the NLRP3 inflammasome and is able to assemble the NLRP3 inflammasome. |
|
T62808 |
NLRP3-IN-6
|
|
|
|
NLRP3-IN-6 (Compound 34) is a selective inhibitor of the NLRP3 inflammasome. |
|
T38360 |
NBC 19
|
|
|
|
Potent NLRP3 inflammasome inhibitor (IC50 = 60-80 nM). Inhibits nigericin- and ATP-induced IL-1β release.
Baldwin et al (2017) Boron-Based Inhibitors of the NLRP3 Inflammasome. Cell Chem.Biol. 24 1321 PMID:28943355 |Red... |
|
T26432 |
A68930
|
A 68930,A70108,A-68930,A 70108,A-70108 |
|
|
A 68930 is a dopamine D-1 receptor antagonist. A 68930 inhibits NLRP3 inflammasome activity. |
|
T61826 |
NLRP3-IN-4
|
|
|
|
NLRP3-IN-4 is a highly efficient and orally bioavailable inhibitor of NLRP3 inflammasome, which exhibits strong anti-inflammatory properties specifically targeted towards colitis. |
|
T71314 |
GL-V9
|
|
|
|
GL-V9 is an AMPK activator, protecting against colitis-associated colorectal cancer by limiting NLRP3 inflammasome through autophagy. |
|
T39552 |
NLRP3-IN-5
|
NLRP3-IN-5 |
|
|
NLRP3-IN-5, a compound disclosed in WO2016131098, is an inhibitor of NLRP3 inflammasome. It consists of the chemical structure N-((4-chloro-2,6-dimethylphenyl)carbamoyl)-4-(2-hydroxypropan-2-l)furan-2-sulfonamide. |
|
T78613 |
Selnoflast calcium
|
RO-7486967 calcium |
NOD-like Receptor (NLR)
|
|
Selnoflast calcium (example 6), an NLRP3 inhibitor[1], is a chemical compound designed to suppress the activity of the NLRP3 inflammasome. |
|
T9655 |
NBC 6
|
|
|
|
NLRP3-IN-NBC6 is a potent, selective NLRP3 inflammasome inhibitor with IC50 of 574 nM. NLRP3-IN-NBC6 acts independently of Ca 2+. NLRP3-IN-NBC6 inhibits Nigericin -induced inflammasome activation in THP-1 cells and Imiqu... |
|
T78822 |
JT002
|
|
NOD-like Receptor (NLR)
|
|
JT002 is an orally active NLRP3 inflammasome inhibitor that decreases the production of NLRP3-dependent proinflammatory cytokines (such as IL-1β, IL-1α, IL-18) and pyroptosis, as well as inhibits the formation of the NLR... |
|
T81665 |
NLRP3-IN-23
|
|
NOD-like Receptor (NLR)
|
|
NLRP3-IN-23 (Compound 15C) is an inhibitor that significantly impedes heme-mediated activation of the NLRP3 inflammasome at a concentration of 0.1 μM [1]. |
|
T73034 |
NLRP3-IN-12
|
|
|
|
NLRP3-IN-12 is a specific inhibitor of the NLRP3 inflammasome, effectively reducing IL-1β release by targeting the NLRP3 protein, and demonstrating an IC50 of 0.45 μM. This compound is utilized in the research of inflamm... |
|
T73014 |
NLRP3-IN-15
|
|
|
|
NLRP3-IN-15 is a potent, selective inhibitor of the NLRP3 inflammasome, demonstrating efficacy by inhibiting IL-1β (interleukin-1 beta) release with an IC50 value of 0.114 μM. This compound is utilized in the research of... |
|
T38106 |
JC-171
|
|
|
|
JC-171, a selective inhibitor of the NLRP3 inflammasome, effectively inhibits LPS/ATP-induced interleukin-1β (IL-1β) release from J774A.1 macrophages with an IC50 of 8.45 μM[1]. |
|
T68225 |
Fc 11a-2
|
|
|
|
Fc 11a-2, a benzimidazole compound, functions as an orally active, potent inhibitor of the NLRP3 inflammasome. It effectively hinders the NLRP3 inflammasome formation by blocking caspase-1 activation and consequently the... |
|
T73013 |
NLRP3-IN-14
|
|
|
|
NLRP3-IN-14 is a potent, selective inhibitor of the NLRP3 inflammasome, displaying a dissociation constant (K D) of 5.87 μM and an IC50 of 0.131 μM for inhibiting IL-1β release. It is applicable for inflammation research... |
|
T73015 |
NLRP3-IN-16
|
|
NOD-like Receptor (NLR)
|
|
NLRP3-IN-16 is a potent, selective inhibitor of the NLRP3 inflammasome, effectively reducing IL-1β release with an IC50 of 0.065 μM, and is primarily utilized in inflammation research [1]. |
|
T79695 |
NLRP3-IN-19
|
NLRP3-IN-19 |
NOD-like Receptor (NLR)
|
|
JT001 (NLRP3-IN-19) is a potent, specific, and orally active NLRP3 inhibitor that impedes the assembly of the NLRP3 inflammasome. This action results in the suppression of cytokine release and prevention of pyroptosis. J... |
|
T76111 |
Hexokinase (ScHEX1)
|
|
|
|
Hexokinase (ScHEX1), a glycolytic enzyme, is inhibited by n-acetylglucosamine, which causes it to detach from the mitochondrial outer membrane. This detachment activates the NLRP3 inflammasome [1]. |
|
T79696 |
JT001 sodium
|
NLRP3-IN-19 sodium |
NOD-like Receptor (NLR)
|
|
JT001 (NLRP3-IN-19) sodium is a potent, specific, and orally active NLRP3 inhibitor that impedes the assembly of the NLRP3 inflammasome, thus curbing cytokine release and averting pyroptosis. It is utilized in research f... |
|
T69745 |
GDC-2394
|
|
|
|
GDC-2394, an orally active, selective NLRP3 inhibitor, also targets IL-1β, exhibiting inhibitory concentrations (IC50s) of 0.4 μM (human IL-1β) and 0.1 μM (mouse IL-1β). It effectively hampers NLRP3-induced caspase-1 act... |
|
T62221 |
NLRP3-IN-8
|
|
|
|
NLRP3-IN-8 (compound 27), an orally active NLRP3 inflammasome inhibitor, directly binds to its target with an IC50 of 1.23 μM for IL-1β inhibition. It demonstrates robust metabolic stability in liver microsomes (t1/2 = 1... |
|
T79733 |
NLRP3-IN-20
|
|
NOD-like Receptor (NLR)
|
|
NLRP3-IN-20 (compound 11) is an orally administered inhibitor targeting the NLRP3 inflammasome, exhibiting potent inhibition with an IC50 of 25 nM against IL-1β secretion. It possesses excellent pharmacokinetic propertie... |
|
T78639 |
Oxidized ATP trisodium salt
|
oATP trisodium salt |
P2X Receptor
|
|
Oxidized ATP trisodium salt (oATP) is a broad-spectrum inhibitor of P2 receptors, irreversibly antagonizing P2X7R activation and inhibiting c-reactive protein (CRP)-induced NLRP3 inflammasome activation. It is utilized i... |
|
T82621 |
D359-0396
|
|
NOD-like Receptor (NLR)
|
|
D359-0396 is an orally active NLRP3 inflammasome inhibitor that mitigates pyroptosis and reduces IL-1β release in macrophages by inhibiting the oligomerization of NLRP3, ASC, and the cleavage of GSDMD. This compound is e... |
|
T78061 |
Peptide5 TFA
|
|
Gap Junction Protein
|
|
Peptide5 TFA, a connexin 43 mimetic peptide, mitigates swelling, astrogliosis, and neuronal cell death in animal models of spinal cord injury. Additionally, it suppresses the NLRP3 inflammasome, functioning as an anti-in... |
|
T79585 |
Anti-inflammatory agent 50
|
|
NF-κB
|
|
Anti-inflammatory agent 50 (compound a1), a derivative of Fusidic acid, exerts its effects through inhibition of inflammatory mediators including NO, IL-6, and TNF-α. It mitigates acute lung injury by modulating these me... |
|
T71651 |
GSK1370319A
|
|
|
|
GSK1370319A is a potent P2X7 antagonist (IC50 = 3.2 nM). GSK1370319A inhibits ATP-induced increase in IL-1β release and caspase 1 activation in lipopolysaccharide (LPS)-primed mixed glia by blocking assembly of the infla... |
|
T60356 |
Stavudine sodium
|
|
|
|
Stavudine sodium (d4T), an orally active nucleoside reverse transcriptase inhibitor (NRTI), demonstrates activity against both HIV-1 and HIV-2. It also inhibits mitochondrial DNA (mtDNA) replication, reduces NLRP3 inflam... |
|
T81637 |
NT-0796
|
|
NOD-like Receptor (NLR)
|
|
NT-0796, a selective CNS-penetrant NLRP3 inflammasome inhibitor, exhibits potent inhibitory activity with an IC50 of 0.32 nM in PBMC assays. As an isopropyl ester, it is metabolized intracellularly into NDT-19795, its ac... |
|
T81579 |
P2X7 receptor antagonist-4
|
|
|
|
Compound 14a (P2X7 receptor antagonist-4) is a P2X7R antagonist with IC50 values of 64.7 nM in humans and 10.1 nM in mice. It inhibits the activation of the NLRP3 inflammasome, which subsequently reduces the expression o... |
|
T73337 |
Articaine
|
Hoe-045 free base |
|
|
Articaine (Hoe-045 free base), an amide anesthetic featuring an ester group, effectively relieves pain by reversibly binding to the α-subunit of the voltage-gated sodium channels located in the nerve's inner cavity. Furt... |
